Yes and no. No because they are not drastically different mouthpieces. Yes because they are still pretty different. The Meyer is a jazz piece and the Vandoren a more all around piece, so the response will feel immediately different. The Vandoren will most likely not respond as quickly as the Meyer. But thats just the way it goes for classical pieces, sacrifice a little response for a potentially drastically different tone. The tip opening on the Vandoren, I believe, is a little bigger than your Meyer. This will make controlling your sound a little more difficult too, particularly with a classical tone. Just keep in mind not to bunch your chin muscles, bring the corners of your lips pushed in, and use a slower air stream than your would on the Meyer. Always have a good sound concept in your mind of what a great classical saxophone should sound like. Also, have you tryed the V12s before? I've heard mixed reviews, so you might like them, but I thought they were garbage.